The effect of various fungi on mouse tumors with special reference to sarcoma 37.

peated these experiments, not only with yeasts, but also with "Oidium" albicans, which lysed tu mor cells. These experiments and those of Lewisohn et al. (3) were reviewed in an earlier paper (2) in which we confirmed the lytic action of sev eral species of Candida on Sarcoma 37 ascites and Ehrlich ascites tumors in miro. Some inhibition of mitosis in Sarcoma 37 ascites cells in vivo, with re duction of ascites swelling, was observed following intraperitoneal injection of nonpathogenic species of Candida. However, with a single exception, there was no prolongation of survival time. Cells of the pathogenic species, Candida albicans, were quickly phagocytized by leukocytes, and the effect on the ascites tumor in vivowas negligible. Exami nation of the influence of Candida species, as well as some other yeastlike organisms and molds on solid tumors (5), showed that many of these or ganisms caused tumor regression. The result of treating solid Sarcoma 37 with these organisms is the subject of the present paper.